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Parathyroid Hormone (1-34), bovine

CAS No. 12583-68-5

Parathyroid Hormone (1-34), bovine( —— )

Catalog No. M33742 CAS No. 12583-68-5

Parathyroid Hormone (1-34), bovine, a parathyroid hormone (PTH) receptor agonist from the parathyroid hormone family, is used to study osteoporosis and hypoparathyroidism.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 135 Get Quote
5MG 187 Get Quote
10MG 282 Get Quote
25MG 453 Get Quote
50MG 660 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Parathyroid Hormone (1-34), bovine
  • Note
    Research use only, not for human use.
  • Brief Description
    Parathyroid Hormone (1-34), bovine, a parathyroid hormone (PTH) receptor agonist from the parathyroid hormone family, is used to study osteoporosis and hypoparathyroidism.
  • Description
    Parathyroid Hormone (1-34), bovine is a potent parathyroid hormone (PTH) receptor agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis.
  • In Vitro
    Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) are added to the medium, it inhibits osteoblast proliferation in a dose-dependent manner. In another group, bPTH are added to the culture medium from day 1 to day 10, but not from days 11 to 20, a rebound of proliferation is observed in the PTH Day 1–10 group after bPTH withdrawal.Parathyroid Hormone (1-34), bovine (0.1-100 ng/mL; 2-20 days) induces diverse effects on the calcium and phosphorus content of culture medium. The calcium and phosphorus content of culture medium in the PTH-C 100 ng/mL group are higher than in teh control group.Cell Proliferation Assay Cell Line: MC3T3-E1 cells Concentration:0.1-100 ng/mL Incubation Time:2-20 days Result:Resulted a decrease of osteoblast proliferationin concentration-dependent manner.
  • In Vivo
    Parathyroid Hormone (1-34)(subcutaneous?injection; 80 μg/kg; 5 days) increases serum osteocalcin concentrations without changing serum inorganic phosphate or calcium concentrations in either group of old animals.?Serum 1,25-dihydroxyvitamin D concentrations are significantly higher in the PTH-treated senile female rats than the sex-matchedvehicle-treated controls.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    THR
  • Recptor
    Thyroid hormone receptor(THR)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    12583-68-5
  • Formula Weight
    4104.39
  • Molecular Formula
    C183H288N54O50S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 50 mg/mL (12.17 mM; Ultrasonic)
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. B H Mitlak, et al. Intermittent administration of bovine PTH-(1-34) increases serum 1,25-dihydroxyvitamin D concentrations and spinal bone density in senile (23 month) rats. J Bone Miner Res. 1992 May;7(5):479-84.?
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